Description

4-Bromo-1-(Fluoromethyl)-2-Methylbenzene is a high-purity halogenated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its unique molecular architecture, combining bromine and fluorine substituents on a methylbenzene core, which enables precise structural modifications in target molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the fluorine atom enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated organic electronic materials for displays and lighting applications.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form complex biaryl structures.
• Fluorine Chemistry Research: An important reagent for studying the effects of fluoromethyl groups on aromatic system reactivity and physical properties.
• Fine Chemical Production: Employed in the custom synthesis of specialty chemicals, dyes, and functional materials requiring specific halogenated motifs.

Basic Information

Product Name	4-Bromo-1-(Fluoromethyl)-2-Methylbenzene
CAS No.	1824142-81-5
Molecular Formula	C9H8BrF
Molecular Weight	215.06 g/mol
Synonyms	1-Bromo-4-(fluoromethyl)-3-methylbenzene; 2-Methyl-4-bromobenzyl fluoride; 4-Bromo-2-methylbenzyl fluoride; 3-Methyl-4-bromobenzyl fluoride; (4-Bromo-2-methylphenyl)fluoromethane; 2-Methyl-α-fluoro-4-bromotoluene; α-Fluoro-4-bromo-2-methyltoluene
EINECS	Contact for details

Quality Control

Every batch of 4-Bromo-1-(Fluoromethyl)-2-Methylbenzene is manufactured and tested under a strict quality management system. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing purity, identity, and impurity profiles as confirmed by GC, HPLC, and NMR.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; ensure the container is kept tightly sealed to exclude moisture and stored away from direct light sources.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.