Description

2-Chloro-4-Fluoronicotinamide is a high-purity fluorinated pyridine derivative serving as a critical synthetic intermediate. This compound matters for its role in constructing complex molecular architectures, particularly in the development of novel active pharmaceutical ingredients (APIs) and advanced agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce halogenated motifs for bioactivity or material properties.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, especially kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require fluorinated pyridine cores.
• Chemical Research & Development: Serves as a versatile substrate for cross-coupling reactions, amide transformations, and further functionalization in medicinal and process chemistry.
• Material Science Precursor: Employed in the development of specialty polymers, liquid crystals, and organic electronic materials where fluorination modulates properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.

Basic Information

Product Name	2-Chloro-4-Fluoronicotinamide
CAS No.	1823944-18-8
Molecular Formula	C6H4ClFN2O
Molecular Weight	174.56 g/mol
Synonyms	2-Chloro-4-fluoropyridine-3-carboxamide; 3-Carbamoyl-2-chloro-4-fluoropyridine; Nicotinamide, 2-chloro-4-fluoro-; 4-Fluoro-2-chloronicotinamide; 2-Chloro-4-fluoro-3-pyridinecarboxamide; 2-Chloro-4-fluoronicotinic acid amide
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-Fluoronicotinamide is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) with complete batch data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.