Description

1-(3-Bromo-5-Fluoropyridin-2-Yl)Ethanone is a high-value brominated and fluorinated pyridine derivative, serving as a critical building block in modern synthetic chemistry. This compound matters because its unique halogenated structure provides versatile reactivity for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and advanced agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific halogenated motifs into their target compounds.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, especially in kinase inhibitor and central nervous system (CNS) active compound research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of halogenated pyridine cores.
• Material Science Precursor: Serves as a starting material for creating functionalized ligands, organic semiconductors, and liquid crystal compounds.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions due to the reactive bromine substituent.
• Functional Group Transformation: The acetyl group allows for further derivatization to alcohols, amines, and heterocycles, expanding the chemical space for discovery libraries.

Basic Information

Product Name	1-(3-Bromo-5-Fluoropyridin-2-Yl)Ethanone
CAS No.	1820641-72-2
Molecular Formula	C7H5BrFNO
Molecular Weight	218.03 g/mol
Synonyms	2-Acetyl-3-bromo-5-fluoropyridine; 3-Bromo-5-fluoro-2-acetylpyridine; Ethanone, 1-(3-bromo-5-fluoro-2-pyridinyl)-; 1-(3-Bromo-5-fluoropyridin-2-yl)ethan-1-one; 2-Pyridineethanone, 3-bromo-5-fluoro-; 3-Bromo-5-fluoro-2-pyridinyl methyl ketone
EINECS	Contact for details

Quality Control

Our 1-(3-Bromo-5-Fluoropyridin-2-Yl)Ethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, impurity profiles, and physical data. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere such as nitrogen or argon to prevent degradation. Keep away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.