Description

4-((2-(2-(2-(2-(4-Aminophenoxy)Ethoxy)Ethoxy)Ethoxy)Ethyl)Amino)-2-(2,6-Dioxopiperidin-3-Yl)Isoindoline-1,3-Dione is a sophisticated bifunctional linker molecule designed for advanced bioconjugation and targeted drug delivery applications. Its core value lies in the precise integration of a pomalidomide-derived cereblon-binding moiety with a hydrophilic, amine-terminated polyethylene glycol (PEG) spacer, enabling the development of novel Proteolysis-Targeting Chimeras (PROTACs) and antibody-drug conjugates (ADCs). This high-purity chemical intermediate is essential for pharmaceutical R&D teams and fine chemical manufacturers focused on next-generation therapeutic modalities.

Application

• PROTAC (Proteolysis-Targeting Chimera) Development: Serves as a critical linker-warhead component, connecting an E3 ubiquitin ligase ligand (from pomalidomide) to a target protein-binding moiety via its amine-functionalized PEG chain.
• Antibody-Drug Conjugate (ADC) Payload-Linker Synthesis: Functions as a versatile linker-payload, where the amine group facilitates conjugation to antibodies, and the dioxopiperidine moiety acts as the cytotoxic or targeted protein degradation agent.
• Bifunctional Crosslinking Agent: Used in bioconjugation chemistry to create stable, site-specific linkages between biomolecules (e.g., proteins, peptides, oligonucleotides) and other functional entities like fluorophores, drugs, or solid supports.
• Targeted Protein Degradation Research: A key building block for academic and industrial research into novel molecular glues and degrader platforms beyond traditional PROTACs.
• High-Value Pharmaceutical Intermediate: Employed in the multi-step synthesis of complex investigational new drugs (INDs) and clinical candidates in oncology and other therapeutic areas.
• Solubility-Enhancing Modifier: The integrated PEG chain can be utilized to improve the aqueous solubility and pharmacokinetic properties of hydrophobic drug candidates.

Basic Information

Product Name	4-((2-(2-(2-(2-(4-Aminophenoxy)Ethoxy)Ethoxy)Ethoxy)Ethyl)Amino)-2-(2,6-Dioxopiperidin-3-Yl)Isoindoline-1,3-Dione
CAS No.	1818885-63-0
Molecular Formula	C29H36N4O9
Molecular Weight	584.62 g/mol
Synonyms	Pomalidomide-PEG4-amine; 2-(2,6-Dioxopiperidin-3-yl)-4-((2-(2-(2-(2-(4-aminophenoxy)ethoxy)ethoxy)ethoxy)ethyl)amino)isoindoline-1,3-dione; Pomalidomide-PEG4-NH2; Pomalidomide-(PEG)4-amine; Aminophenyl-PEG4-pomalidomide; 4-((17-Amino-3,6,9,12-tetraoxaheptadec-1-yl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 1818885-63-0; Pomalidomide PEG amine
EINECS	Contact for details

Quality Control

Our 4-((2-(2-(2-(2-(4-Aminophenoxy)Ethoxy)Ethoxy)Ethoxy)Ethyl)Amino)-2-(2,6-Dioxopiperidin-3-Yl)Isoindoline-1,3-Dione is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, critical for sensitive pharmaceutical applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support development under cGMP guidelines and can tailor quality documentation to meet specific regulatory submission requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible. For long-term storage (over 12 months), consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.