Description

Cdk8/19-In-1 CAS NO 1818427-07-4 is a potent and selective small molecule inhibitor targeting the cyclin-dependent kinases 8 and 19 (CDK8/19), key regulators of the Mediator complex and transcription. This compound matters for researchers and developers as it provides a critical tool for investigating transcriptional dysregulation in oncology, inflammation, and other disease areas. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on developing novel therapeutics targeting transcriptional control pathways.

Application

• Biochemical Research: Used as a reference standard and active probe in enzymatic assays to study CDK8/19 kinase activity and inhibition mechanisms.
• Oncology Drug Discovery: Serves as a lead compound or pharmacological tool for validating CDK8/19 as a therapeutic target in various cancer models, including colorectal, breast, and hematological malignancies.
• Transcriptional Regulation Studies: Applied in cell-based assays to dissect the role of the Mediator complex in gene expression and signal transduction pathways.
• Inflammatory Disease Research: Utilized to investigate the involvement of CDK8/19 in inflammatory responses and immune cell function for potential autoimmune disease applications.
• High-Throughput Screening (HTS): Employed as a control compound in screening campaigns to identify novel CDK8/19 inhibitors or modulators.
• Preclinical Development: Supports in vitro and in vivo pharmacokinetic/pharmacodynamic (PK/PD) studies during the early stages of therapeutic candidate optimization.

Basic Information

Product Name	Cdk8/19-In-1
CAS No.	1818427-07-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Cdk8/19-In-1; CDK8/19 inhibitor 1; 1818427-07-4; Cdk8/19 Inhibitor; CDK8 Inhibitor; CDK19 Inhibitor; Transcriptional CDK Inhibitor; Mediator Kinase Inhibitor
EINECS	Contact for details

Quality Control

Our Cdk8/19-In-1 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions to maintain stability, as the compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the product to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.