Description

Pf-06650833 is a high-purity, small molecule chemical compound identified by the CAS registry number 1817626-54-2. This compound is of significant interest in pharmaceutical research and development, particularly as a potent and selective inhibitor of Interleukin-1 Receptor-Associated Kinase 4 (IRAK4). It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of novel therapeutics for autoimmune, inflammatory, and oncological indications, where modulation of innate immune signaling pathways is a key target.

Application

• Pharmaceutical R&D: Serves as a critical reference standard and active pharmaceutical ingredient (API) intermediate in drug discovery programs targeting IRAK4.
• Biochemical Research: Used as a potent tool compound in in vitro and cellular assays to study TLR/IL-1R signaling pathways and their role in disease mechanisms.
• Preclinical Studies: Employed in animal model research to evaluate the efficacy and pharmacokinetics of IRAK4 inhibition for potential therapeutic applications.
• Process Chemistry: Acts as a key building block for the synthesis of more complex molecules or prodrugs in medicinal chemistry optimization.

Basic Information

Product Name	Pf-06650833
CAS No.	1817626-54-2
Molecular Formula	C₂₀H₂₀N₆O₂
Molecular Weight	376.41 g/mol
Synonyms	PF 06650833; PF-06650833; 8-Fluoro-2-[(2S,5R)-5-methyl-1-(6-methyl-3-pyridazinyl)-2-pyrrolidinyl]quinoline; IRAK4 Inhibitor PF-06650833; 8-Fluoro-2-[(2S,5R)-5-methyl-1-(6-methylpyridazin-3-yl)pyrrolidin-2-yl]quinoline; BMS-986147 (discontinued code); (2S,5R)-8-Fluoro-2-[5-methyl-1-(6-methyl-3-pyridazinyl)-2-pyrrolidinyl]quinoline
EINECS	Contact for details

Quality Control

Our Pf-06650833 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with our stringent specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.