Description

Biotinyl Adrenocorticotropic Hormone (1-39) (Human) is a synthetic, biotinylated peptide fragment corresponding to the biologically active N-terminal sequence of the human adrenocorticotropic hormone (ACTH). This modification is critical for research applications requiring high-affinity detection, isolation, or quantification of ACTH and its receptors. It serves as an essential biochemical tool for scientists in endocrinology, neuroscience, and pharmacology. The compound is primarily utilized in advanced research and development, including immunoassay development, receptor binding studies, and proteomic analysis.

Application

• Biochemical Research & Assay Development: Used as a labeled tracer or capture reagent in ELISA, RIA, and other immunoassays for ACTH quantification.
• Receptor Binding & Signal Transduction Studies: Employed to investigate the binding affinity and activation mechanisms of the melanocortin 2 receptor (MC2R).
• Affinity Purification & Pull-Down Assays: The biotin tag enables efficient isolation of ACTH-binding proteins or receptor complexes using streptavidin-coated beads.
• Proteomics & Biomarker Discovery: Acts as a molecular probe to identify and characterize proteins that interact with the ACTH (1-39) sequence.
• Pharmaceutical R&D: Supports drug discovery efforts targeting the HPA axis, including the screening and evaluation of novel therapeutics for endocrine disorders.
• Diagnostic Kit Manufacturing: Serves as a key raw material (API intermediate) in the production of in-vitro diagnostic kits for cortisol-related conditions.

Basic Information

Product Name	Biotinyl Adrenocorticotropic Hormone (1-39) (Human)
CAS No.	1816258-26-0
Molecular Formula	C207H310N56O58S
Molecular Weight	4638.1 g/mol (approx.)
Synonyms	Biotin-ACTH (1-39), human; Biotinylated Adrenocorticotropin (1-39); Biotin-ACTH1-39; Biotinylated Corticotropin; Biotin-Labeled ACTH; N-Biotinyl-ACTH (human); ACTH (1-39), Biotin conjugate; Biotin-Ser1-Tyr2-Ser3-Met4-Glu5-His6-Phe7-Arg8-Trp9-Gly10-Lys11-Pro12-Val13-Gly14-Lys15-Lys16-Arg17-Arg18-Pro19-Val20-Lys21-Val22-Tyr23-Pro24-Asp25-Gly26-Ala27-Glu28-Asp29-Glu30-Ser31-Ala32-Glu33-Ala34-Phe35-Pro36-Leu37-Glu38-Phe39
EINECS	Contact for details

Quality Control

Our Biotinyl Adrenocorticotropic Hormone (1-39) (Human) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide full traceability and documentation. A Certificate of Analysis (COA) detailing purity, peptide content, and analytical results is supplied with every shipment to ensure compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture absorption. Store away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC-MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Peptide Content (AAA)	≥ 80%
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 1.0%
Acetate Content (IC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.