Description

Dgkα Inhibitor Cu-3 is a potent and selective small-molecule inhibitor targeting the diacylglycerol kinase alpha (DGKα) enzyme. This compound is a critical research tool for modulating T-cell activation and cytokine signaling pathways, offering significant value in immunological and oncology research. It is essential for pharmaceutical R&D, academic institutions, and biotechnology companies focused on developing novel immunotherapies and cancer treatments. The product is supplied as a high-purity reference standard, identified by CAS NO 1815598-71-0.

Application

• Immunology Research: Used to study T-cell receptor (TCR) signaling, anergy, and immune synapse formation by inhibiting DGKα-mediated conversion of diacylglycerol (DAG) to phosphatidic acid (PA).
• Oncology & Cancer Immunotherapy: Investigated for its potential to enhance anti-tumor immune responses by preventing the attenuation of DAG signaling in T-cells and natural killer (NK) cells.
• Biochemical Assay Development: Serves as a key reference compound and positive control in high-throughput screening (HTS) campaigns to discover new DGKα modulators.
• Signal Transduction Studies: A vital tool for elucidating the role of DGKα in various cellular processes, including cell proliferation, migration, and apoptosis.
• Preclinical Drug Discovery: Used in in vitro and in vivo models to validate DGKα as a therapeutic target for autoimmune diseases, transplant rejection, and cancer.

Basic Information

Product Name	Dgkα Inhibitor Cu-3
CAS No.	1815598-71-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	DGKα Inhibitor Cu3; CU-3; Diacylglycerol Kinase Alpha Inhibitor Cu-3; DGK Inhibitor Cu-3; 1815598-71-0; DGKα Inhibitor; (Chemical Name Pending); Research Compound CU-3
EINECS	Contact for details

Quality Control

Our Dgkα Inhibitor Cu-3 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and batch-specific data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.