Description

Mcl1-In-3 CAS NO 1814891-79-6 is a potent and selective small-molecule inhibitor of the myeloid cell leukemia 1 (Mcl-1) protein, a key anti-apoptotic regulator in the Bcl-2 family. This compound is a critical research tool for investigating programmed cell death pathways and their role in cancer biology, particularly in hematological malignancies and solid tumors where Mcl-1 overexpression is associated with therapeutic resistance. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on oncology drug discovery and the development of novel apoptosis-targeting therapies.

Application

• Biochemical Research: Used as a reference standard and pharmacological probe to study the structure, function, and inhibition kinetics of the Mcl-1 protein in vitro.
• Oncology Drug Discovery: Serves as a lead compound or a positive control in high-throughput screening (HTS) campaigns to identify and validate new Mcl-1 inhibitor scaffolds.
• Mechanistic Studies: Employed in cell-based assays to elucidate the role of Mcl-1 in apoptosis evasion, chemoresistance, and tumor cell survival across various cancer cell lines.
• Preclinical Development: Supports in vivo efficacy and pharmacokinetic/pharmacodynamic (PK/PD) studies in animal models of cancer to evaluate therapeutic potential.
• Combinatorial Therapy Research: Investigated in combination with other targeted agents (e.g., Bcl-2 inhibitors, chemotherapeutics) to explore synergistic effects and overcome drug resistance.

Basic Information

Product Name	Mcl1-In-3
CAS No.	1814891-79-6
Molecular Formula	C30H31N5O3S
Molecular Weight	541.66 g/mol
Synonyms	Mcl1-In-3; Mcl-1 inhibitor 3; 1814891-79-6; MCL1-IN-3; (S)-N-((S)-1-Cyclohexyl-2-((4-(4-(ethylsulfonyl)piperazin-1-yl)phenyl)amino)-2-oxoethyl)-2-(4-(4-methylthiazol-5-yl)phenyl)propenamide; UNC-XXXX; Compound 21 (from literature); Mcl-1 protein inhibitor
EINECS	Contact for details

Quality Control

Every batch of Mcl1-In-3 is manufactured under strict quality management systems and undergoes comprehensive analytical characterization to ensure identity, purity, and batch-to-batch consistency. Our standard research-grade material is characterized by NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) containing purity data, chromatograms, and spectral information is provided with each shipment to support your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert atmosphere for long-term stability. For short-term use, the material may be stored at 2-8°C. The compound is moisture-sensitive; allow the vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.