Description

Map4K4-In-17 is a potent and selective small molecule inhibitor of Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4), a key signaling node implicated in inflammatory and metabolic pathways. This compound is a critical research tool for elucidating the role of MAP4K4 in disease models, particularly in oncology, immunology, and metabolic disorder research. It is essential for pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on kinase-targeted drug discovery and pathway analysis.

Application

• Biochemical Research: Used as a selective probe to study MAP4K4 signaling cascades and their downstream effects in cellular models.
• Drug Discovery & Development: Serves as a lead compound or reference standard in high-throughput screening and structure-activity relationship (SAR) studies for kinase inhibitor programs.
• Oncology Research: Investigated for its potential to inhibit cancer cell proliferation, migration, and invasion in preclinical studies targeting MAP4K4-dependent tumors.
• Immunology & Inflammation Studies: Applied in research exploring the role of MAP4K4 in immune cell activation, cytokine production, and inflammatory disease models.
• Metabolic Disease Research: Utilized in studies examining insulin signaling, glucose homeostasis, and adipocyte function where MAP4K4 is a potential therapeutic target.
• Academic & Contract Research: A vital reagent for universities and CROs conducting fundamental research on kinase biology and intracellular signal transduction.

Basic Information

Product Name	Map4K4-In-17
CAS No.	1811510-58-3
Molecular Formula	C₂₀H₂₀N₆O₂
Molecular Weight	376.42 g/mol
Synonyms	MAP4K4 Inhibitor-17; 6-(4-(4-Methylpiperazin-1-yl)phenyl)-N-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-3-amine; HG-9-91-01; HG-9-91-01 analog; MAP4K4 inhibitor compound 17; MAPK kinase kinase kinase 4 inhibitor
EINECS	Contact for details

Quality Control

Our Map4K4-In-17 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.