Description

3-Fluoro-4-(Trimethylsilyl)Pyridine-2-Carboxylic Acid is a high-value, multifunctional heterocyclic building block featuring both a carboxylic acid and a trimethylsilyl-protected position. This compound matters for its role as a key synthetic intermediate in the development of complex molecules, particularly in pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists in the life sciences sector for constructing novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, especially in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides with tailored properties.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organometallic chemistry.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probes: Utilized to create tagged or modified molecules for studying biological pathways and protein interactions.
• Custom Synthesis and Contract Manufacturing: A key starting material for custom synthesis projects requiring fluorinated and silylated pyridine scaffolds.

Basic Information

Product Name	3-Fluoro-4-(Trimethylsilyl)Pyridine-2-Carboxylic Acid
CAS No.	1809168-70-4
Molecular Formula	C10H14FNO2Si
Molecular Weight	227.31 g/mol
Synonyms	2-Pyridinecarboxylic acid, 3-fluoro-4-(trimethylsilyl)-; 3-Fluoro-4-(trimethylsilyl)picolinic acid; 4-(Trimethylsilyl)-3-fluoropyridine-2-carboxylic acid; 3-Fluoro-4-trimethylsilylpyridine-2-carboxylic acid; TMS-Fluoropicolinic Acid; CAS 1809168-70-4
EINECS	Contact for details

Quality Control

Our 3-Fluoro-4-(Trimethylsilyl)Pyridine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP and ISO standards for pharmaceutical and fine chemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a dry environment to prevent degradation. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.