Description

3-Flouro-2-Iodo-4-(Trimethylsilyl)Pyridine is a high-value, multi-functionalized pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique combination of fluorine, iodine, and trimethylsilyl substituents on the pyridine ring makes it a versatile intermediate for constructing complex molecular architectures. This compound is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly in medicinal chemistry for creating fluorinated and iodinated heterocycles.
• Agrochemical Research: Used in the development of new pesticides and herbicides, where the fluorine and iodine atoms can enhance biological activity and environmental stability.
• Ligand Synthesis: Serves as a starting material for the preparation of specialized ligands used in catalysis and material science.
• Functional Material Development: Employed in the creation of advanced organic electronic materials and liquid crystals due to its modified pyridine core.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Sonogashira) to form complex biaryl systems.
• Fluorination Chemistry Studies: Used as a model compound in methodological development for introducing and manipulating fluorine atoms in heteroaromatic systems.

Basic Information

Item	Details
Product Name	3-Flouro-2-Iodo-4-(Trimethylsilyl)Pyridine
CAS No.	1809161-43-0
Molecular Formula	C8H11FINSi
Molecular Weight	295.17 g/mol
Synonyms	4-(Trimethylsilyl)-3-fluoro-2-iodopyridine; 2-Iodo-3-fluoro-4-(trimethylsilyl)pyridine; 3-Fluoro-2-iodo-4-trimethylsilylpyridine; 3-F-2-I-4-TMS-Pyridine; Pyridine, 3-fluoro-2-iodo-4-(trimethylsilyl)-; TMS-Protected Fluoroiodopyridine
EINECS	Contact for details

Quality Control

Every batch of 3-Flouro-2-Iodo-4-(Trimethylsilyl)Pyridine is manufactured and tested under strict quality management protocols to ensure consistency and reliability for research and development purposes. Our products undergo rigorous analytical testing, including HPLC, NMR, and GC-MS, to confirm identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.