Description

5-Bromo-3,4-Difluoro-2-(Trimethylsilyl)Benzaldehyde is a high-value, multi-functional aromatic aldehyde building block. This compound is engineered for advanced synthetic chemistry, offering a unique combination of halogen and silicon functionalities for precise molecular construction. It is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging its halogenated aromatic core.
• Material Science Research: Serves as a building block for creating functionalized organic semiconductors, liquid crystals, and advanced polymers.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions.
• Directed Ortho Metalation (DoM): The trimethylsilyl group acts as a powerful directing and protecting group for further functionalization of the aromatic ring.
• Fluorine Chemistry: The difluoro motif is valuable for modulating lipophilicity, metabolic stability, and bioavailability in drug design.

Basic Information

Product Name	5-Bromo-3,4-Difluoro-2-(Trimethylsilyl)Benzaldehyde
CAS No.	1809158-01-7
Molecular Formula	C10H11BrF2OSi
Molecular Weight	293.18 g/mol
Synonyms	2-(Trimethylsilyl)-5-bromo-3,4-difluorobenzaldehyde; 5-Bromo-3,4-difluoro-2-(trimethylsilyl)benzaldehyde; Benzaldehyde, 5-bromo-3,4-difluoro-2-(trimethylsilyl)-; 1809158-01-7; 5-Br-3,4-F2-2-TMS-benzaldehyde
EINECS	Contact for details

Quality Control

Our 5-Bromo-3,4-Difluoro-2-(Trimethylsilyl)Benzaldehyde is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing including HPLC, GC, NMR, and mass spectrometry to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.