Description

3-Fluoro-4-(Trimethylsilyl)Pyridine-2-Carbaldehyde is a high-value, multi-functional organosilicon building block. This compound is essential for advanced organic synthesis, particularly in the development of novel pharmaceuticals and agrochemicals. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex heterocyclic systems.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for drugs targeting the central nervous system or as kinase inhibitors.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides, fungicides, and insecticides with enhanced efficacy.
• Ligand and Catalyst Development: Serves as a versatile scaffold for creating novel ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probes: Useful for designing molecular probes and tags due to its reactive aldehyde group and fluorine atom.
• Cross-Coupling Reactions: The trimethylsilyl group can act as a protective group or be utilized in silicon-based cross-coupling methodologies.

Basic Information

Product Name	3-Fluoro-4-(Trimethylsilyl)Pyridine-2-Carbaldehyde
CAS No.	1809157-89-8
Molecular Formula	C9H12FNOSi
Molecular Weight	197.29 g/mol
Synonyms	2-Formyl-3-fluoro-4-(trimethylsilyl)pyridine; 3-Fluoro-4-(trimethylsilyl)picolinaldehyde; 4-(Trimethylsilyl)-3-fluoropyridine-2-carboxaldehyde; 3-Fluoro-4-trimethylsilylpyridine-2-carbaldehyde; 2-Pyridinecarboxaldehyde, 3-fluoro-4-(trimethylsilyl)-; 3-Fluoro-4-TMS-pyridine-2-carbaldehyde
EINECS	Contact for details

Quality Control

Our 3-Fluoro-4-(Trimethylsilyl)Pyridine-2-Carbaldehyde is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with customer specifications and industry standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white solid or light yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Typical 97-99%)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.