Description

(S)-1-(6-(Trifluoromethyl)Pyridin-3-Yl)Ethanol is a high-purity, single-enantiomer chiral building block essential for modern pharmaceutical and agrochemical research. This compound matters because its specific stereochemistry and trifluoromethylpyridine moiety are critical for developing active ingredients with enhanced metabolic stability, bioavailability, and target selectivity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical industry for the synthesis of novel drug candidates, particularly in areas like kinase inhibitors and central nervous system (CNS) agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the asymmetric synthesis of active pharmaceutical ingredients (APIs).
• Agrochemical Research: Used in developing advanced herbicides and pesticides with improved efficacy and environmental profiles.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands used in asymmetric catalysis.
• Material Science: Potential building block for specialty polymers and liquid crystals.
• Chemical Biology: Useful as a probe or tag in medicinal chemistry and biochemical studies.
• Process Chemistry: Employed in route scouting and scale-up optimization for commercial manufacturing.

Basic Information

Product Name	(S)-1-(6-(Trifluoromethyl)Pyridin-3-Yl)Ethanol
CAS No.	1807940-49-3
Molecular Formula	C8H8F3NO
Molecular Weight	191.15 g/mol
Synonyms	(S)-1-[6-(Trifluoromethyl)pyridin-3-yl]ethanol; (S)-α-(Trifluoromethyl)pyridinemethanol; (S)-1-(6-(Trifluoromethyl)-3-pyridinyl)ethanol; (S)-[6-(Trifluoromethyl)pyridin-3-yl]ethanol; (S)-5-(1-Hydroxyethyl)-2-(trifluoromethyl)pyridine; (S)-2-(Trifluoromethyl)-5-(1-hydroxyethyl)pyridine; (S)-TFMPE; (S)-Trifluoromethylpyridine Ethanol
EINECS	Contact for details

Quality Control

Our (S)-1-(6-(Trifluoromethyl)Pyridin-3-Yl)Ethanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, to ensure compliance with high-purity standards for research and development. Certificates of Analysis (COA) with detailed specifications for identity, purity, and chiral purity are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.