Description

2-Fluoro-5-Methyl-Isonicotinonitrile is a high-purity, multi-functional chemical building block. This compound is valued for its unique pyridine core substituted with fluorine and nitrile groups, which are critical for modulating the physicochemical and biological properties of target molecules. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in kinase inhibitor and CNS-active compound libraries.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and pesticides, where the fluorine atom enhances biological activity and metabolic stability.
• Material Science Research: Serves as a precursor for functionalized ligands and organic electronic materials due to its electron-withdrawing nitrile group.
• Chemical Biology Probes: Employed in the design of molecular probes and tags for studying biological systems and enzyme mechanisms.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and complex molecules under cGMP conditions.

Basic Information

Product Name	2-Fluoro-5-Methyl-Isonicotinonitrile
CAS No.	1807299-66-6
Molecular Formula	C7H5FN2
Molecular Weight	136.13 g/mol
Synonyms	5-Methyl-2-fluoropyridine-4-carbonitrile; 2-Fluoro-5-methyl-4-cyanopyridine; 4-Cyano-2-fluoro-5-methylpyridine; Isonicotinonitrile, 2-fluoro-5-methyl-; 2-Fluoro-5-methylisonicotinonitrile; 2-Fluoro-5-methyl-4-pyridinecarbonitrile
EINECS	Contact for details

Quality Control

Our 2-Fluoro-5-Methyl-Isonicotinonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with each shipment, supporting your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.