Description

Benzene, 2-Bromo-3,4-Difluoro-1-Methyl- is a high-purity, multi-functional halogenated aromatic building block, identified by CAS NO 1807187-70-7. This compound is valued for its unique substitution pattern, offering a reactive bromine site and fluorine atoms for tuning electronic properties and metabolic stability in advanced syntheses. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing complex drug candidates, particularly where fluorine atoms are used to enhance bioavailability and binding affinity.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the halogenated structure for biological activity.
• Material Science Research: Serves as a precursor for developing specialty polymers, liquid crystals, and organic electronic materials due to its aromatic core and halogen functionalities.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Negishi, and Stille couplings to create complex biaryl structures.
• Fluorine Chemistry Studies: Used as a model compound in research exploring the effects of difluoro substitution on aromatic system reactivity and physical properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific halogenated intermediates.

Basic Information

Product Name	Benzene, 2-Bromo-3,4-Difluoro-1-Methyl-
CAS No.	1807187-70-7
Molecular Formula	C7H5BrF2
Molecular Weight	207.02 g/mol
Synonyms	2-Bromo-3,4-difluorotoluene; 1-Bromo-2,3-difluoro-4-methylbenzene; 3,4-Difluoro-2-bromotoluene; 2-Bromo-3,4-difluoro-1-methylbenzene; Toluene, 2-bromo-3,4-difluoro-; 4-Methyl-2,3-difluorobromobenzene; Bromodifluorotoluene
EINECS	Contact for details

Quality Control

Our Benzene, 2-Bromo-3,4-Difluoro-1-Methyl- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) documenting purity, assay, and impurity profiles are available for every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.