Description

2-Fluoro-4-Methylpyridine-3-Carbonitrile is a versatile fluorinated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both fluorine and nitrile functional groups, makes it a valuable intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the fluorine atom enhances biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers and liquid crystals.
• Chemical Biology Probes: Employed in the design of molecular probes and inhibitors for studying enzyme mechanisms and biological pathways.
• Organic Light-Emitting Diode (OLED) Materials: Acts as an electron-transporting or host material precursor in the manufacture of advanced display technologies.
• Cross-Coupling Reactions: A valuable substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) for constructing biaryl systems.

Basic Information

Product Name	2-Fluoro-4-Methylpyridine-3-Carbonitrile
CAS No.	1807136-76-0
Molecular Formula	C7H5FN2
Molecular Weight	136.13 g/mol
Synonyms	3-Cyano-2-fluoro-4-methylpyridine; 4-Methyl-2-fluoropyridine-3-carbonitrile; 2-Fluoro-4-methyl-3-pyridinecarbonitrile; 2-Fluoro-4-picolinonitrile; 2-Fluoro-4-methylnicotinonitrile; 1807136-76-0; 2-Fluoro-4-methyl-3-cyanopyridine
EINECS	Contact for details

Quality Control

Our 2-Fluoro-4-Methylpyridine-3-Carbonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. Due to its light-sensitive nature, containers should be kept in opaque packaging or amber glass.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.