Description

4-Chloro-2,3-Difluorobenzyl Chloride is a versatile and highly reactive benzyl halide derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic placement of chlorine and fluorine substituents, which enable precise molecular modifications to tune the properties of target compounds. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for molecules requiring a difluorobenzyl moiety.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the chloro-difluoro pattern enhances biological activity and environmental stability.
• Liquid Crystal & OLED Material Production: Serves as a building block for fluorinated aromatic compounds used in electronic display technologies.
• Polymer & Resin Modification: Employed to introduce functional benzyl groups into polymer chains, altering physical and chemical properties.
• Cross-Coupling Reactions: An effective substrate in palladium-catalyzed reactions like Suzuki, Heck, and Stille couplings for constructing complex biaryl systems.
• Organic Synthesis Research: A valuable reagent in academic and industrial R&D for exploring new fluorination methodologies and creating specialized chemical libraries.

Basic Information

Product Name	4-Chloro-2,3-Difluorobenzyl Chloride
CAS No.	1807133-11-4
Molecular Formula	C7H4Cl2F2
Molecular Weight	213.01 g/mol
Synonyms	1-(Chloromethyl)-4-chloro-2,3-difluorobenzene; (4-Chloro-2,3-difluorophenyl)methyl chloride; 2,3-Difluoro-4-chlorobenzyl chloride; α,4-Dichloro-α,2,3-trifluorotoluene; 4-Chloro-2,3-difluorobenzylchloride; 4-Chloro-2,3-difluoro-benzyl chloride
EINECS	Contact for details

Quality Control

Our 4-Chloro-2,3-Difluorobenzyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.