Description

Benzene, 2-Bromo-1-Chloro-4-Fluoro-3-Methyl- CAS NO 1806971-78-7 is a highly functionalized, multi-halogenated benzene derivative, serving as a critical building block in advanced organic synthesis. Its precise halogen substitution pattern makes it an invaluable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop new active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the halogen atoms contribute to biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a core structure for creating advanced electronic materials, including liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs), due to its ability to modify molecular polarity and conformation.
• Polymer & Resin Modifier: Incorporated into specialty polymers to enhance flame retardancy, thermal stability, and chemical resistance for high-performance engineering plastics.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi) to form complex biaryl structures prevalent in many functional materials.
• Chemical Research & Development: A versatile reagent in academic and industrial R&D labs for exploring new synthetic methodologies and creating compound libraries for screening.

Basic Information

Product Name	Benzene, 2-Bromo-1-Chloro-4-Fluoro-3-Methyl-
CAS No.	1806971-78-7
Molecular Formula	C7H5BrClF
Molecular Weight	223.47 g/mol
Synonyms	1-Bromo-2-chloro-5-fluoro-6-methylbenzene; 2-Bromo-1-chloro-4-fluoro-3-methylbenzene; 3-Methyl-2-bromo-1-chloro-4-fluorobenzene; 6-Methyl-3-bromo-2-chloro-1-fluorobenzene; Bromochlorofluoromethylbenzene (isomer); BCFMB (abbrev.); Halogenated Toluene Derivative
EINECS	Contact for details

Quality Control

Our Benzene, 2-Bromo-1-Chloro-4-Fluoro-3-Methyl- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing identity, assay, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C/59-77°F). Keep away from heat, sparks, and open flame. Due to its sensitivity to light and organic solvent nature, ensure containers are kept sealed when not in use to prevent evaporation and maintain purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.