Description

2-Bromo-3-(trifluoromethyl)isonicotinonitrile is a high-value, multi-functional heterocyclic building block designed for advanced synthetic chemistry. This compound is critical for researchers and process chemists developing novel active pharmaceutical ingredients (APIs) and agrochemicals, where the introduction of bromine and trifluoromethyl groups is strategically valuable. Its primary utility lies in facilitating cross-coupling reactions and serving as a precursor for complex molecular architectures in life science R&D.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, leveraging the bioactivity-enhancing properties of the trifluoromethyl group.
• Material Science Research: Serves as a precursor for functionalized pyridine derivatives used in organic electronic materials and metal-organic frameworks (MOFs).
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions to create complex biaryl systems.
• Fluorine Chemistry Building Block: Essential for introducing the metabolically stable and lipophilic trifluoromethyl moiety into target molecules.

Basic Information

Product Name	2-Bromo-3-(trifluoromethyl)isonicotinonitrile
CAS No.	1806850-59-8
Molecular Formula	C7H2BrF3N2
Molecular Weight	250.99 g/mol
Synonyms	2-Bromo-3-(trifluoromethyl)pyridine-4-carbonitrile; 4-Cyano-2-bromo-3-(trifluoromethyl)pyridine; 3-(Trifluoromethyl)-2-bromoisonicotinonitrile; 2-Bromo-3-trifluoromethylisonicotinonitrile; 1806850-59-8; 2-Bromo-3-(trifluoromethyl)-4-pyridinecarbonitrile
EINECS	Contact for details

Quality Control

Our production of 2-Bromo-3-(trifluoromethyl)isonicotinonitrile adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for your critical synthesis. Each lot is characterized by advanced analytical techniques including NMR, HPLC, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.