Description

5-Methoxy-6-(trifluoromethyl)nicotinic acid is a high-value, multi-functional chemical intermediate characterized by its unique trifluoromethyl-substituted pyridine core. This compound is of significant commercial interest due to its role in modulating the physicochemical properties of target molecules, particularly in enhancing metabolic stability and lipophilicity. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in developing kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group contributes to biological activity and environmental stability.
• Material Science Research: Serves as a precursor for functionalized ligands and monomers in the development of specialty polymers and advanced organic materials.
• Chemical Biology & Proteomics: Employed as a molecular probe or a tagging reagent in biochemical research to study protein interactions and cellular pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes in fine chemical manufacturing.

Basic Information

Product Name	5-Methoxy-6-(Trifluoromethyl)Nicotinic Acid
CAS No.	1806497-13-1
Molecular Formula	C8H6F3NO3
Molecular Weight	221.13 g/mol
Synonyms	5-Methoxy-6-(trifluoromethyl)pyridine-3-carboxylic acid; 3-Pyridinecarboxylic acid, 5-methoxy-6-(trifluoromethyl)-; 6-(Trifluoromethyl)-5-methoxynicotinic acid; 5-Methoxy-6-trifluoromethylnicotinic acid; 1806497-13-1; Nicotinic acid, 5-methoxy-6-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our production of 5-Methoxy-6-(trifluoromethyl)nicotinic acid adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting all critical parameters are provided and available upon request, supporting compliance in regulated development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.