Description

Methyl 2,4-Difluoropyridine-3-Carboxylate CAS NO 1806304-70-0 is a high-purity fluorinated pyridine derivative, serving as a critical advanced pharmaceutical intermediate (API intermediate) and versatile building block in organic synthesis. Its value lies in the strategic placement of fluorine atoms and the ester functional group, which are essential for modulating the biological activity, metabolic stability, and physicochemical properties of target molecules. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting central nervous system (CNS) disorders, oncology, and anti-infective agents.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the difluoropyridine moiety can enhance potency and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands used in catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of fluorinated organic electronic materials and liquid crystals.
• Custom Synthesis & Contract Manufacturing: A starting material for custom synthesis projects requiring specific fluorinated heterocyclic architectures.
• Academic & Industrial R&D: Fundamental research reagent for exploring new chemical reactions and synthesizing complex molecular libraries for screening.

Basic Information

Product Name	Methyl 2,4-Difluoropyridine-3-Carboxylate
CAS No.	1806304-70-0
Molecular Formula	C7H5F2NO2
Molecular Weight	173.12 g/mol
Synonyms	2,4-Difluoropyridine-3-carboxylic acid methyl ester; Methyl 2,4-difluoronicotinate; 3-Pyridinecarboxylic acid, 2,4-difluoro-, methyl ester; 2,4-Difluoro-3-pyridinecarboxylic acid methyl ester; Methyl 2,4-difluoro-3-pyridinecarboxylate; 3-Carbomethoxy-2,4-difluoropyridine; 2,4-Difluoronicotinic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 2,4-Difluoropyridine-3-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.