Description

4-Amino-3-Trifluoromethyl-Pyridine-2-Carbonitrile is a high-value, multi-functional heterocyclic building block characterized by its amino, nitrile, and trifluoromethyl substituents. This compound is essential for medicinal chemistry and agrochemical research, enabling the rapid synthesis of novel molecules with enhanced biological activity and metabolic stability. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, leveraging the trifluoromethyl group for improved lipophilicity and bioactivity.
• Ligand Synthesis: Serves as a precursor for creating specialized ligands in catalysis and metal-organic frameworks (MOFs).
• Material Science: Incorporated into the design of advanced organic electronic materials and functional polymers.
• Chemical Biology: Employed as a probe or labeling agent due to its reactive functional groups.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes under cGMP conditions.

Basic Information

Product Name	4-Amino-3-Trifluoromethyl-Pyridine-2-Carbonitrile
CAS No.	1805601-57-3
Molecular Formula	C7H4F3N3
Molecular Weight	187.12 g/mol
Synonyms	2-Cyano-4-amino-3-(trifluoromethyl)pyridine; 3-(Trifluoromethyl)-4-aminopyridine-2-carbonitrile; 4-Amino-3-trifluoromethylpicolinonitrile; 2-Pyridinecarbonitrile, 4-amino-3-(trifluoromethyl)-; 4-Amino-3-(trifluoromethyl)-2-pyridinecarbonitrile
EINECS	Contact for details

Quality Control

Every batch of 4-Amino-3-Trifluoromethyl-Pyridine-2-Carbonitrile is manufactured under strict quality management systems. We provide comprehensive analytical documentation to ensure the material meets the rigorous standards required for research and development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for all shipments. Our quality protocols are designed to support regulatory filings in key global markets.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. This material is light-sensitive and should be stored away from light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.