Description

1-Bromo-5-Fluoro-3-Iodo-2-Methylbenzene is a high-purity, multi-halogenated aromatic building block of significant value in advanced organic synthesis. Its unique structure, featuring bromine, fluorine, and iodine substituents on a methylbenzene core, makes it a versatile intermediate for constructing complex molecules. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications such as Suzuki-Miyaura cross-coupling and the synthesis of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially in drug discovery and development programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the introduction of halogen atoms can modulate biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Sonogashira) due to the presence of reactive bromo and iodo groups, allowing for sequential functionalization.
• Chemical Research & Development: Employed in academic and industrial R&D labs for methodology development, library synthesis, and exploring new chemical spaces in medicinal and synthetic chemistry.
• Ligand and Catalyst Design: Used to synthesize complex, polydentate ligands for catalysis or as a scaffold for creating novel organocatalysts.

Basic Information

Product Name	1-Bromo-5-Fluoro-3-Iodo-2-Methylbenzene
CAS No.	1805552-81-1
Molecular Formula	C7H5BrFI
Molecular Weight	314.92 g/mol
Synonyms	2-Bromo-4-fluoro-6-iodo-1-methylbenzene; 3-Bromo-1-fluoro-5-iodo-2-methylbenzene; 2-Methyl-1-bromo-5-fluoro-3-iodobenzene; 5-Fluoro-3-iodo-2-methylbromobenzene; Benzene, 1-bromo-5-fluoro-3-iodo-2-methyl-; 1805552-81-1
EINECS	Contact for details

Quality Control

Every batch of 1-Bromo-5-Fluoro-3-Iodo-2-Methylbenzene is manufactured and tested under strict quality management protocols to ensure consistency and high purity for critical synthetic applications. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and storage should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.