Description

5-Bromo-1-(difluoromethyl)-2,3-difluorobenzene is a high-purity, multi-functional fluorinated aromatic building block. This compound is valued for its unique combination of bromine and fluorine substituents, which enable precise structural modifications in advanced synthesis. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates. Its specific substitution pattern makes it a critical reagent for introducing fluorinated motifs into complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoromethyl and bromo groups contribute to enhanced biological activity and metabolic stability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic electronic materials requiring specific fluorine content.
• Cross-Coupling Reactions: The bromine atom acts as an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi, Stille) to form new carbon-carbon bonds.
• Fluorine Chemistry Research: An essential reagent in methodological studies and the exploration of new fluorination techniques and reaction pathways in academic and industrial R&D settings.
• Ligand and Catalyst Development: Utilized for constructing sophisticated, fluorinated ligands for metal catalysis and organocatalysts.

Basic Information

Product Name	5-Bromo-1-(difluoromethyl)-2,3-difluorobenzene
CAS No.	1805422-92-7
Molecular Formula	C7H3BrF4
Molecular Weight	242.99 g/mol
Synonyms	2,3-Difluoro-5-bromo-α,α-difluorotoluene; 1-Bromo-3,4-difluoro-5-(difluoromethyl)benzene; 5-Bromo-α,α,2,3-tetrafluorotoluene; Benzene, 5-bromo-1-(difluoromethyl)-2,3-difluoro-; 1805422-92-7; 5-Bromo-2,3-difluoro-α,α-difluorotoluene
EINECS	Contact for details

Quality Control

Every batch of 5-Bromo-1-(difluoromethyl)-2,3-difluorobenzene is manufactured and tested under a strict quality management system. We guarantee high chemical purity and consistency, supported by comprehensive analytical characterization including GC, HPLC, NMR, and MS. A detailed Certificate of Analysis (COA) specifying identity, purity, and impurity profiles is provided with each shipment to ensure it meets your precise research and process requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and reactive metals. The container should be kept tightly sealed in a dry environment to prevent moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.