Description

2-Chloro-4-Fluoro-3-Nitrotoluene is a high-purity halogenated aromatic intermediate of significant importance in advanced organic synthesis. This compound matters for its role as a versatile building block in the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors. Industrial and R&D chemists need it for constructing active pharmaceutical ingredients (APIs), crop protection agents, and other specialty chemicals where the introduction of specific halogen and nitro substituents is critical for biological activity and material properties.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in the development of fluorinated pharmaceuticals where the fluorine atom enhances metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, leveraging the nitro and halogen groups for targeted biological activity.
• Material Science Research: Serves as a precursor for the development of specialty polymers, liquid crystals, and organic electronic materials.
• Dye and Pigment Intermediate: Employed in the synthesis of complex, color-fast dyes and pigments for industrial applications.
• Cross-Coupling Reactions: An effective substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) for creating biaryl structures.
• Organic Synthesis Research: A valuable reagent in academic and industrial R&D for exploring new synthetic methodologies and constructing complex molecular architectures.

Basic Information

Product Name	2-Chloro-4-Fluoro-3-Nitrotoluene
CAS No.	1805115-44-9
Molecular Formula	C7H5ClFNO2
Molecular Weight	189.57 g/mol
Synonyms	1-Chloro-2-fluoro-5-methyl-3-nitrobenzene; 3-Nitro-2-chloro-4-fluorotoluene; Toluene, 2-chloro-4-fluoro-3-nitro-; 2-Chloro-4-fluoro-3-nitro-1-methylbenzene; 2-Chloro-4-fluoro-3-nitromethylbenzene; Benzene, 1-chloro-2-fluoro-5-methyl-3-nitro-; (2-Chloro-4-fluoro-3-nitrophenyl)methane (incorrect but common search variant)
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-Fluoro-3-Nitrotoluene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for critical synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber-colored or stored in dark conditions.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.