Description

4-Difluoromethyl-3-Methoxy-Pyridin-2-Ylamine is a high-purity, advanced pharmaceutical intermediate characterized by its unique pyridine core with difluoromethyl and methoxy substituents. This compound is critical for medicinal chemistry research and the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring fluorine-containing motifs for enhanced metabolic stability and bioavailability. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, especially kinase inhibitors and other small molecule therapeutics.
• Agrochemical Research: Used in the development of new pesticides and herbicides, where the difluoromethyl group can improve biological activity and environmental profile.
• Medicinal Chemistry: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Chemical Biology: Employed as a probe or precursor in the development of chemical tools for studying biological systems.
• Fine Chemical Synthesis: A valuable precursor for the preparation of more complex, functionalized pyridine derivatives used in various specialty chemical applications.

Basic Information

Product Name	4-Difluoromethyl-3-Methoxy-Pyridin-2-Ylamine
CAS No.	1805029-25-7
Molecular Formula	C8H8F2N2O
Molecular Weight	186.16 g/mol
Synonyms	2-Amino-4-(difluoromethyl)-3-methoxypyridine; 3-Methoxy-4-(difluoromethyl)pyridin-2-amine; 4-(Difluoromethyl)-3-methoxypyridin-2-amine; 2-Pyridinamine, 4-(difluoromethyl)-3-methoxy-; 1805029-25-7
EINECS	Contact for details

Quality Control

Our 4-Difluoromethyl-3-Methoxy-Pyridin-2-Ylamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong acids and strong oxidizing agents. For long-term storage, consider maintaining the material under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.