Description

1,5-Dichloro-2-Fluoro-3-Iodobenzene is a high-purity halogenated benzene derivative designed for advanced synthetic chemistry. This compound serves as a critical multi-functional building block, offering three distinct halogen handles for selective cross-coupling and functional group transformations. It is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel active ingredients. Its unique substitution pattern enables precise molecular architecture in complex organic synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging its halogen diversity for structure-activity relationship (SAR) studies.
• Material Science Research: Employed as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki-Miyaura, Stille, and Sonogashira couplings, where the iodine and chlorine atoms offer orthogonal reactivity.
• Ligand and Catalyst Development: Serves as a backbone for synthesizing novel phosphine, N-heterocyclic carbene (NHC), and other specialty ligands used in catalysis.
• Chemical Biology & Proteomics: Utilized as a tagging or labeling reagent for bioconjugation and probe development due to its reactive halogen sites.

Basic Information

Product Name	1,5-Dichloro-2-Fluoro-3-Iodobenzene
CAS No.	1804514-77-9
Molecular Formula	C6H2Cl2FI
Molecular Weight	304.89 g/mol
Synonyms	3-Iodo-1,5-dichloro-2-fluorobenzene; 2-Fluoro-3-iodo-1,5-dichlorobenzene; 1,5-Dichloro-2-fluoro-3-iodo-benzene; Benzene, 1,5-dichloro-2-fluoro-3-iodo-; 1804514-77-9 (CAS)
EINECS	Contact for details

Quality Control

Every batch of 1,5-Dichloro-2-Fluoro-3-Iodobenzene is manufactured and analyzed under strict quality management systems. We guarantee high chemical purity and lot-to-lot consistency suitable for demanding research and scale-up processes. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) with detailed chromatographic data (HPLC/GC) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maximize shelf-life stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.