Description

3,4-Difluoropyridin-2-Amine is a high-purity fluorinated pyridine derivative, a key building block in modern organic synthesis. This compound matters for its role as a versatile intermediate in the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors. It is needed by research chemists and process development scientists for creating novel active ingredients, where the introduction of fluorine atoms is critical for modulating biological activity, metabolic stability, and lipophilicity.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitors and central nervous system (CNS) targeted drugs.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, where fluorinated pyridines enhance efficacy and environmental profile.
• Material Science Research: Serves as a building block for creating advanced organic materials, such as ligands for catalysts or components in electronic materials.
• Chemical Biology & Proteomics: Employed in the design and synthesis of molecular probes and tool compounds for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scaled-up production under cGMP conditions for clinical trial materials.

Basic Information

Product Name	3,4-Difluoropyridin-2-Amine
CAS No.	1804379-06-3
Molecular Formula	C5H4F2N2
Molecular Weight	130.10 g/mol
Synonyms	2-Amino-3,4-difluoropyridine; 3,4-Difluoro-2-pyridinamine; 3,4-Difluoropyridin-2-ylamine; 2-Pyridinamine, 3,4-difluoro-; 3,4-Difluoro-2-aminopyridine
EINECS	Contact for details

Quality Control

Our 3,4-Difluoropyridin-2-Amine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports applications from early-stage research to pre-clinical and commercial-scale GMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.