Description

4-Fluoro-2-Hydroxynicotinic Acid is a fluorinated derivative of hydroxynicotinic acid, serving as a high-value pharmaceutical intermediate and versatile chemical building block. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique fluorine substitution and bifunctional groups enable precise molecular modifications. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced material sectors for constructing complex heterocyclic frameworks.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the development of new herbicides and pesticides, leveraging the fluorine atom for enhanced bioactivity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for chelating ligands in metal-catalyzed cross-coupling reactions and coordination chemistry.
• Material Science Research: Employed in the creation of functionalized organic molecules for electronic materials and organic semiconductors.
• Chemical Biology Probes: Useful for synthesizing fluorinated probes and tags for studying biological processes and enzyme mechanisms.
• Custom Synthesis & Contract Manufacturing: A starting material for custom synthesis projects requiring specific fluorinated nicotinic acid derivatives.

Basic Information

Product Name	4-Fluoro-2-Hydroxynicotinic Acid
CAS No.	1803770-09-3
Molecular Formula	C6H4FNO3
Molecular Weight	157.10 g/mol
Synonyms	2-Hydroxy-4-fluoronicotinic Acid; 4-Fluoro-2-hydroxypyridine-5-carboxylic Acid; 5-Carboxy-4-fluoro-2-hydroxypyridine; 4-Fluoro-2-oxo-1,2-dihydropyridine-5-carboxylic Acid; 1803770-09-3; 4-Fluoro-2-hydroxy-5-pyridinecarboxylic Acid; 4-Fluoro-2-pyridone-5-carboxylic Acid
EINECS	Contact for details

Quality Control

Our 4-Fluoro-2-Hydroxynicotinic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Due to its acidic nature, keep away from incompatible materials such as strong bases and oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.