Description

4-(Trifluoromethyl)Piperidin-2-One is a high-value, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the unique combination of the piperidinone scaffold and the metabolically stable trifluoromethyl group, which is crucial for modulating the physicochemical properties of target molecules. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the discovery and development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of central nervous system (CNS) active drugs, enzyme inhibitors, and other bioactive molecules.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides where the trifluoromethyl group enhances lipophilicity and biological activity.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science: Investigated as a monomer or additive for creating specialty polymers with unique surface properties.
• Chemical Biology: Employed as a probe or tag in medicinal chemistry for structure-activity relationship (SAR) studies.
• Custom Synthesis: A versatile starting material for contract research organizations (CROs) and CDMOs producing complex, fluorinated target compounds for clients.

Basic Information

Product Name	4-(Trifluoromethyl)Piperidin-2-One
CAS No.	1803588-50-2
Molecular Formula	C6H8F3NO
Molecular Weight	167.13 g/mol
Synonyms	4-(Trifluoromethyl)-2-piperidinone; 4-(Trifluoromethyl)piperidin-2-one; 2-Piperidinone, 4-(trifluoromethyl)-; 4-Trifluoromethyl-2-piperidone; 4-(Trifluoromethyl)-2-piperidone; α,α,α-Trifluoro-4-piperidone
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethyl)Piperidin-2-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.