Description

Protac Ripk Degrader-2 is a potent and selective small-molecule degrader designed to target Receptor-Interacting Serine/Threonine-Protein Kinase (RIPK) for proteasomal degradation. This compound matters as a critical research tool for investigating necroptosis, inflammation, and related disease pathways, offering a powerful alternative to traditional kinase inhibitors. It is primarily needed by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on oncology, neurodegenerative disorders, and autoimmune disease research. The product is supplied under strict quality control to ensure reliable and reproducible experimental results.

Application

• Biomedical Research: A key chemical probe for studying the biological functions and signaling pathways of RIPK1 and RIPK2.
• Drug Discovery & Development: Used in target validation and as a lead compound in the development of novel therapeutics targeting inflammatory and cell death pathways.
• Mechanistic Studies: Enables investigation into necroptosis and its role in conditions like ischemia-reperfusion injury, sepsis, and inflammatory bowel disease.
• Oncology Research: Utilized to explore the role of RIPK in tumor progression, metastasis, and resistance to chemotherapy.
• Neurodegenerative Disease Models: Applied in research models for Alzheimer's disease, Amyotrophic Lateral Sclerosis (ALS), and Multiple Sclerosis to understand neuroinflammation.
• In Vitro & In Vivo Assays: Serves as a critical reagent in high-throughput screening (HTS) and preclinical animal studies to assess efficacy and pharmacokinetics.

Basic Information

Product Name	Protac Ripk Degrader-2
CAS No.	1801547-16-9
Molecular Formula	C₄₀H₄₈ClN₉O₇
Molecular Weight	802.33 g/mol
Synonyms	PROTAC RIPK Degrader-2; RIPK Degrader-2; Degrader of RIPK; RIPK1/2 PROTAC; (1S,2R,4S,5S)-4-((4-(((S)-1-((4-chlorophenyl)ethyl)carbamoyl)cyclopropyl)methyl)piperazin-1-yl)-2-((4-((3-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)propyl)carbamoyl)phenyl)carbamoyl)-7-oxabicyclo[3.2.1]octan-5-yl acetate; Bivalent RIPK Degrader
EINECS	Contact for details

Quality Control

Our Protac Ripk Degrader-2 is manufactured under controlled conditions to ensure the highest standards of purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via mass spectrometry (MS) and nuclear magnetic resonance (NMR). Comprehensive Certificates of Analysis (COA) detailing all specifications are provided to guarantee traceability and support your regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive); ensure the original container is sealed tightly after each use and allowed to equilibrate to room temperature before opening to prevent condensation. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.