Description

Losartan Carboxylic Acid Acyl-β-D-Glucuronide is a major, pharmacologically active metabolite of the antihypertensive drug Losartan. This compound is critical for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and bioanalytical method validation. It serves as a high-purity reference standard for laboratories in the pharmaceutical, biotechnology, and contract research organization (CRO) sectors, enabling accurate quantification and characterization of Losartan and its metabolites in biological matrices.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for quantitative analysis in drug development and regulatory submissions.
• Metabolite Identification & Profiling: Essential for in vitro and in vivo ADME (Absorption, Distribution, Metabolism, Excretion) studies to understand Losartan's metabolic pathways.
• Bioanalytical Method Development: Used to develop and validate robust HPLC, LC-MS, and LC-MS/MS methods for therapeutic drug monitoring and pharmacokinetic studies.
• Impurity Characterization: Acts as a known impurity or degradation product standard for Losartan drug substance and product quality control.
• Clinical Research: Supports clinical trials by providing a benchmark for measuring metabolite levels in patient plasma or serum samples.
• Toxicology Studies: Utilized in safety assessment to investigate the potential effects of the major circulating metabolite.

Basic Information

Product Name	Losartan Carboxylic Acid Acyl-β-D-Glucuronide
CAS No.	1799830-02-6
Molecular Formula	C30H34N6O10
Molecular Weight	638.63 g/mol
Synonyms	E-3174 Glucuronide; Losartan Carboxylic Acid Glucuronide; EXP-3174 Glucuronide; Losartan Metabolite Glucuronide; 2-Butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid, β-D-Glucopyranosiduronic acid ester; (2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazol-5-yl)methyl β-D-Glucopyranosiduronic Acid
EINECS	Contact for details

Quality Control

This high-grade material is produced under strict quality management systems. Each batch is characterized and tested using advanced analytical techniques including NMR, HPLC, and LC-MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing batch-specific results. Our quality protocols are designed to meet the rigorous standards expected by pharmaceutical R&D and regulatory laboratories.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This compound is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.