Description

n-(3-(2-(2-(3-Aminopropoxy)Ethoxy)Ethoxy)Propyl)-2-((2-(2,6-Dioxopiperidin-3-Yl)-1,3-Dioxoisoindolin-4-Yl)Oxy)Acetamide Trifluoroacetate is a high-purity, synthetic small molecule compound designed for advanced research and development applications. This compound is of significant interest for its potential role as a key intermediate or active component in the development of novel therapeutic agents, particularly in targeted protein degradation and oncology research. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on innovative drug discovery platforms.

Application

• Proteolysis-Targeting Chimera (PROTAC) Development: Serves as a critical linker-warhead conjugate for constructing bifunctional molecules designed to degrade specific disease-causing proteins.
• Pharmaceutical Intermediates: Acts as a sophisticated building block in the multi-step synthesis of complex investigational new drugs (INDs).
• Biochemical Research: Used as a tool compound in molecular and cellular biology to study protein-protein interactions, ubiquitin-proteasome system (UPS) pathways, and cellular signaling mechanisms.
• Oncology Drug Discovery: Investigated for its application in creating targeted cancer therapies that leverage induced protein degradation.
• Chemical Biology Probes: Employed in the design of selective probes to validate novel drug targets and understand disease biology at a molecular level.
• Academic & Contract Research: Supplied to universities and CROs (Contract Research Organizations) for fundamental and applied research in medicinal chemistry.

Basic Information

Product Name	n-(3-(2-(2-(3-Aminopropoxy)Ethoxy)Ethoxy)Propyl)-2-((2-(2,6-Dioxopiperidin-3-Yl)-1,3-Dioxoisoindolin-4-Yl)Oxy)Acetamide Trifluoroacetate
CAS No.	1799711-29-7
Molecular Formula	C27H35F3N4O11
Molecular Weight	648.59 g/mol
Synonyms	Thalidomide-O-PEG3-NH2 TFA; 4-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)-N-(3-(2-(2-(3-aminopropoxy)ethoxy)ethoxy)propyl)acetamide trifluoroacetate; Thalidomide-PEG3-amine TFA salt; PROTAC Linker 11; Amino-PEG3-thalidomide TFA; E3 Ligase Ligand-Linker Conjugate 15; (S)-N-(3-(2-(2-(3-Aminopropoxy)ethoxy)ethoxy)propyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide 2,2,2-trifluoroacetate
EINECS	Contact for details

Quality Control

Our n-(3-(2-(2-(3-Aminopropoxy)Ethoxy)Ethoxy)Propyl)-2-((2-(2,6-Dioxopiperidin-3-Yl)-1,3-Dioxoisoindolin-4-Yl)Oxy)Acetamide Trifluoroacetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.