Description

3-(Aminomethyl)-4-(Trifluoromethyl)Pyridine 1-Oxide is a high-value, multi-functional heterocyclic building block featuring both an aminomethyl group and a trifluoromethylpyridine N-oxide moiety. This compound matters for its unique reactivity profile, enabling the synthesis of complex molecules with enhanced physicochemical properties, such as improved metabolic stability and membrane permeability. It is primarily needed by researchers and process chemists in the pharmaceutical and agrochemical industries for developing novel active ingredients, particularly in medicinal chemistry for drug discovery programs targeting CNS and inflammatory diseases. The compound is also utilized in material science for creating advanced functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel small-molecule drugs, especially protease inhibitors and kinase modulators.
• Agrochemical Synthesis: Used in creating advanced herbicides and pesticides where the trifluoromethyl group confers biological activity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Precursor: Employed in the synthesis of specialty polymers, liquid crystals, and electronic materials.
• Chemical Biology Probes: Useful for labeling and modifying biomolecules due to its reactive amine handle and fluorinated tag.
• Fluorine Chemistry Research: A valuable substrate for studying the introduction and transformation of fluorine-containing groups in heterocycles.

Basic Information

Product Name	3-(Aminomethyl)-4-(Trifluoromethyl)Pyridine 1-Oxide
CAS No.	1799580-70-3
Molecular Formula	C8H9F3N2O
Molecular Weight	206.17 g/mol
Synonyms	4-(Trifluoromethyl)-3-(aminomethyl)pyridine 1-oxide; 3-(Aminomethyl)-4-(trifluoromethyl)pyridine N-oxide; 4-(Trifluoromethyl)-3-pyridinemethanamine 1-oxide; 3-(Aminomethyl)-α,α,α-trifluoro-4-pyridine N-oxide; 1-Oxido-4-(trifluoromethyl)-3-pyridinemethanamine; (4-(Trifluoromethyl)-1-oxidopyridin-3-yl)methanamine
EINECS	Contact for details

Quality Control

Our 3-(Aminomethyl)-4-(Trifluoromethyl)Pyridine 1-Oxide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring reliability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.