Description

Centrinone-B CAS NO 1798871-31-4 is a potent and selective small-molecule inhibitor of the PLK4 (Polo-like kinase 4) enzyme. This compound is of significant value in biochemical and pharmaceutical research for its role in disrupting centriole duplication, a critical process in cell division. It is primarily utilized by researchers and developers in the fields of oncology, cell biology, and drug discovery for studying cell cycle regulation, centrosome biology, and as a potential lead compound for anticancer therapeutics.

Application

• Oncology Research: Investigation of PLK4 as a therapeutic target for various cancers, including breast cancer and hepatocellular carcinoma.
• Cell Biology Studies: Tool compound for probing centriole biogenesis, centrosome amplification, and mitotic fidelity in cell culture models.
• Drug Discovery & Development: A reference standard and lead compound for the synthesis and screening of novel PLK4 inhibitors.
• Mechanistic Studies: Used to understand the downstream signaling pathways and cellular consequences of PLK4 inhibition.
• Biochemical Assays: High-throughput screening (HTS) and in vitro kinase profiling to assess selectivity and potency.

Basic Information

Product Name	Centrinone-B
CAS No.	1798871-31-4
Molecular Formula	C₂₀H₂₀N₆O₂
Molecular Weight	376.41 g/mol
Synonyms	Centrinone B; (R)-9-(6-Aminopyridin-3-yl)-1-(3,5-difluorophenyl)-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[1,5-a]azepin-5-amine; PLK4 Inhibitor Centrinone-B; Polo-like kinase 4 inhibitor (Centrinone-B); (5R)-9-(6-Amino-3-pyridinyl)-1-(3,5-difluorophenyl)-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[1,5-a]azepin-5-amine
EINECS	Contact for details

Quality Control

Our Centrinone-B is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.