Description

Centrinone CAS NO 1798871-30-3 is a potent and selective small-molecule inhibitor of the PLK4 (Polo-like kinase 4) enzyme, a key regulator of centriole duplication. This compound is a critical research tool for studying cell division, centrosome biology, and the mechanisms underlying genomic instability. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in oncology drug discovery and fundamental cell biology studies.

Application

• Centrosome Biology Research: A fundamental tool for investigating centriole biogenesis, centrosome amplification, and their roles in cellular processes.
• Oncology & Cancer Research: Used to study PLK4 as a therapeutic target in various cancers, particularly those driven by centrosome amplification, such as breast cancer and glioblastoma.
• Cell Cycle & Mitosis Studies: Enables precise inhibition of PLK4 to dissect its function during the cell cycle and its impact on mitotic fidelity.
• Chemical Probe Development: Serves as a starting point or reference compound for the design and validation of novel PLK4 inhibitors.
• Mechanism of Action (MOA) Studies: Employed in target validation and pathway analysis to understand the downstream effects of PLK4 inhibition.
• Preclinical Drug Discovery: Used in in vitro and in vivo models to evaluate the efficacy and therapeutic potential of targeting PLK4.

Basic Information

Item	Details
Product Name	Centrinone
CAS No.	1798871-30-3
Molecular Formula	C₂₀H₂₀N₆O₂
Molecular Weight	376.41 g/mol
Synonyms	Centrinone; (R)-9-(6-Aminopyridin-3-yl)-1-(3,5-difluorophenyl)-6,7-dihydro-5H-benzo[7]annulen-8(9H)-one; BAY-1217389; PLK4 Inhibitor (Centrinone); Polo-like kinase 4 inhibitor (Centrinone); (R)-9-(6-Aminopyridin-3-yl)-1-(3,5-difluorophenyl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-8-one
EINECS	Contact for details

Quality Control

Our Centrinone is produced under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR for structural confirmation, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the exact specifications and test results. We adhere to high standards suitable for preclinical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This compound is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.