Description

(R)-Topotecan CAS NO 1797985-73-9 is the R-enantiomer of the potent topoisomerase I inhibitor Topotecan, representing a critical chiral intermediate and reference standard in pharmaceutical research and development. Its primary value lies in enabling the stereoselective synthesis and analytical characterization of camptothecin-derived anticancer agents, ensuring precise control over biological activity. This high-purity compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors focused on oncology drug discovery, process development, and quality control.

Application

• Pharmaceutical Reference Standard: Used as a certified chiral reference material for HPLC, LC-MS, and NMR analysis to ensure the purity and enantiomeric excess of active pharmaceutical ingredients (APIs).
• Chiral Intermediate in API Synthesis: Serves as a key building block in the stereocontrolled synthesis of novel Topotecan analogs and other camptothecin derivatives for preclinical evaluation.
• Mechanistic & Biochemical Research: Employed in studies to investigate the structure-activity relationship (SAR) and differential biological effects of Topotecan enantiomers on topoisomerase I inhibition.
• Quality Control & Method Development: Critical for developing and validating analytical methods to monitor chiral purity and impurity profiles in bulk drug substances and finished dosage forms.
• Regulatory Submissions: Provides essential data and materials for regulatory filings (e.g., FDA, EMA) requiring characterization of stereoisomers.

Basic Information

Product Name	(R)-Topotecan
CAS No.	1797985-73-9
Molecular Formula	C23H23N3O5
Molecular Weight	421.45 g/mol
Synonyms	(R)-Topotecan; (R)-9-[(Dimethylamino)methyl]-10-hydroxycamptothecin; (R)-Hycamptamine; (R)-SKF 104864-A; (R)-10-Hydroxy-9-[(dimethylamino)methyl]-20(S)-camptothecin; (R)-Enantiomer of Topotecan; (R)-TPT; (19R)-Topotecan
EINECS	Contact for details

Quality Control

Our (R)-Topotecan is manufactured under strict quality management systems to ensure the highest standards of purity and consistency, suitable for research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing critical parameters such as chiral purity, chemical purity (HPLC), and residual solvents. We adhere to relevant industry guidelines to support our customers' quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Yellow to light yellow solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.