Description

E3 Ligase Ligand-Linker Conjugates 12 is a high-purity, synthetic chemical building block designed for the development of Proteolysis Targeting Chimeras (PROTACs) and other targeted protein degradation (TPD) technologies. This compound is critical for constructing bifunctional molecules that recruit E3 ubiquitin ligases to specific disease-causing proteins, marking them for destruction by the cell's natural proteasome system. It is an essential research tool for pharmaceutical R&D teams, medicinal chemists, and academic laboratories focused on oncology, neurodegenerative diseases, and other challenging therapeutic areas where traditional inhibition is insufficient.

Application

• PROTAC Molecule Synthesis: Serves as a key component for constructing novel PROTAC degraders targeting various proteins of interest.
• Medicinal Chemistry & Drug Discovery: Used in hit-to-lead optimization and structure-activity relationship (SAR) studies for TPD platforms.
• Chemical Biology Research: Enables the study of protein function, ubiquitin-proteasome system (UPS) dynamics, and novel degradation pathways.
• Oncology Target Validation: Facilitates the development of degraders for historically "undruggable" oncoproteins.
• Bifunctional Molecule Library Construction: Used to create diverse libraries of degraders for high-throughput screening campaigns.
• Academic & Institutional Research: Supports fundamental research in targeted protein degradation and ubiquitin signaling.

Basic Information

Product Name	E3 Ligase Ligand-Linker Conjugates 12
CAS No.	1797406-80-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	PROTAC Linker Conjugate 12; E3 Ligase Recruiting Ligand-Linker; Targeted Protein Degradation Building Block 12; VHL Ligand-Linker Conjugate (analog); CRBN Ligand-Linker Conjugate (analog); Bifunctional Molecule Intermediate 12; TPD Chemical Tool 12
EINECS	Contact for details

Quality Control

Every batch of E3 Ligase Ligand-Linker Conjugates 12 is manufactured under strict quality management systems and undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Our products are suitable for advanced research and development applications. A detailed Certificate of Analysis (COA) providing HPLC purity, NMR confirmation, and other critical data is supplied with each shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term storage, keep at -20°C or below under inert atmosphere. Allow the product to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation. Store in a cool, dry, well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.