Description

C-Desmethyl Atenolol CAS NO 1797116-92-7 is a key pharmaceutical intermediate and reference standard, specifically a desmethylated metabolite of the widely used β-blocker Atenolol. This compound is of critical importance for analytical research, method development, and quality control in pharmaceutical manufacturing, ensuring the purity and safety of final drug products. It is primarily utilized by research institutions, analytical laboratories, and pharmaceutical companies engaged in drug metabolism studies, impurity profiling, and regulatory compliance testing.

Application

• Pharmaceutical Reference Standard: Used as a certified standard for the quantitative and qualitative analysis of Atenolol and its related substances in drug substances and products.
• Metabolite Research: Serves as a critical metabolite standard in pharmacokinetic and pharmacodynamic studies to understand the drug's behavior in biological systems.
• Impurity Profiling: Essential for identifying, characterizing, and controlling process-related impurities and degradation products in Atenolol API (Active Pharmaceutical Ingredient) manufacturing.
• Analytical Method Development: Employed in the development and validation of chromatographic methods (HPLC, LC-MS) for accurate detection and quantification.
• Quality Control & Assurance: Integral to in-process testing and final release testing to ensure drug product specifications meet pharmacopeial standards (e.g., USP, EP).
• Regulatory Compliance: Supports regulatory filings (IND, NDA, ANDA) by providing necessary data on impurities and degradation pathways as per ICH guidelines.

Basic Information

Product Name	C-Desmethyl Atenolol
CAS No.	1797116-92-7
Molecular Formula	C13H20N2O3
Molecular Weight	252.31 g/mol
Synonyms	4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzamide; Desmethyl Atenolol; Atenolol Desmethyl Impurity; Atenolol Metabolite; 1-(4-Carbamoylmethylphenoxy)-3-isopropylaminopropan-2-ol; UNII-7VMA8Z51Q0; 7VMA8Z51Q0
EINECS	Contact for details

Quality Control

Our C-Desmethyl Atenolol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets high-purity standards suitable for use as a reference material. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment. Our quality commitment aligns with the standards expected for pharmaceutical impurities and metabolites.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.