Description

Orexin 2 Receptor Agonist CAS NO 1796565-52-0 is a potent and selective small molecule agonist targeting the orexin 2 (OX2) receptor, a key regulator of arousal, wakefulness, and energy homeostasis. This high-purity compound is essential for advancing research in neuropharmacology and developing novel therapeutics for sleep-wake disorders such as narcolepsy and idiopathic hypersomnia. It is a critical tool for pharmaceutical R&D teams, academic researchers, and contract research organizations (CROs) focused on central nervous system (CNS) drug discovery and preclinical studies.

Application

• Neuroscience Research: Fundamental studies on orexin receptor signaling, neuronal excitability, and the regulation of sleep-wake cycles.
• Pharmacological Profiling: In vitro and in vivo characterization of OX2 receptor-mediated pathways for lead optimization in drug discovery programs.
• Preclinical Drug Development: Efficacy and safety evaluation in animal models of narcolepsy, cataplexy, and excessive daytime sleepiness (EDS).
• Biochemical Assay Development: Used as a reference standard in high-throughput screening (HTS), calcium flux assays, and radioligand binding studies.
• Mechanism of Action Studies: Investigating the role of the orexin system in appetite regulation, addiction, and metabolic disorders.

Basic Information

Product Name	Orexin 2 Receptor Agonist
CAS No.	1796565-52-0
Molecular Formula	C23H28N4O3S
Molecular Weight	440.56 g/mol
Synonyms	TAK-925; TAK925; (1R,2S)-2-{[(2,4-Dimethylphenyl)sulfonyl]amino}-N-[(5-fluoro-2-pyridinyl)methyl]-1-methyl-2-(3-morpholinyl)ethylcarboxamide; Orexin 2 Receptor Agonist TAK-925; OX2R Agonist; Hypocretin Receptor 2 Agonist; Wake-Promoting Agent
EINECS	Contact for details

Quality Control

Every batch of our Orexin 2 Receptor Agonist is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) detailing HPLC purity, NMR confirmation, and residual solvent analysis. Our quality standards are designed to meet the rigorous requirements of pharmaceutical R&D and preclinical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive). For long-term storage, keep under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.