Description

S-Deprenyl-D3 Hydrochlorid is a deuterium-labeled isotopologue of the selective monoamine oxidase B (MAO-B) inhibitor, Selegiline. This high-purity reference standard is critical for ensuring analytical accuracy and reliability in quantitative research and development. It is primarily utilized by pharmaceutical researchers, analytical laboratories, and contract development and manufacturing organizations (CDMOs) for applications in drug metabolism and pharmacokinetics (DMPK) studies, bioanalytical method development, and as an internal standard for mass spectrometry.

Application

• Internal Standard for LC-MS/MS: Serves as a stable, isotopically labeled internal standard for the precise quantification of Selegiline and its metabolites in complex biological matrices like plasma, serum, and tissue homogenates.
• Drug Metabolism Studies (DMPK): Essential for investigating the absorption, distribution, metabolism, and excretion (ADME) profile of Selegiline, enabling accurate tracking of the parent drug and its deuterated analogs.
• Bioanalytical Method Development and Validation: Used to develop, optimize, and validate robust, sensitive, and specific analytical methods in compliance with GLP and FDA/EMA guidelines.
• Pharmacokinetic and Pharmacodynamic Research: Facilitates accurate pharmacokinetic modeling and helps elucidate the relationship between drug concentration and pharmacological effect.
• Reference Material for Quality Control: Acts as a certified reference material for the quality control and assurance of pharmaceutical products containing Selegiline.
• Neuroscience and Neuropharmacology Research: Supports fundamental research into MAO-B enzyme function and its role in neurological conditions.

Basic Information

Product Name	S-Deprenyl-D3 Hydrochlorid
CAS No.	1795787-02-8
Molecular Formula	C13H14D3ClN
Molecular Weight	221.76 g/mol
Synonyms	(R)-(-)-Deprenyl-D3 hydrochloride; (R)-Selegiline-D3 hydrochloride; (R)-N,α-Dimethyl-N-(2-propynyl)benzeneethanamine-D3 hydrochloride; L-Deprenyl-D3 HCl; (-)-Deprenyl-D3 HCl; (R)-(-)-N,α-Dimethyl-N-2-propynylphenethylamine-D3 hydrochloride; J508-D3 hydrochloride; Elderpryl-D3 hydrochloride
EINECS	Contact for details

Quality Control

Our S-Deprenyl-D3 Hydrochlorid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and specific tests for residual solvents and moisture content. We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing all test results against stringent in-house specifications. Our quality commitment ensures material suitable for demanding research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This compound is hygroscopic (moisture-sensitive); ensure the original container is sealed tightly after each use to minimize exposure to atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D3)	≥98.0 atom % D
Chemical Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.