Description

L-Penicillamine-D6 is a deuterium-labeled isotopologue of the pharmaceutical agent L-Penicillamine, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity compound is essential for ensuring accuracy and reliability in mass spectrometry-based analyses, where it corrects for variations in sample preparation and instrument response. It is a critical material for researchers and quality control laboratories in the pharmaceutical, biotechnology, and contract research organization (CRO) sectors who require precise quantification of Penicillamine in complex biological matrices.

Application

• Internal Standard for LC-MS/MS: Primary application as a stable, non-interfering internal standard for the precise quantification of L-Penicillamine in pharmacokinetic, bioequivalence, and metabolomic studies.
• Pharmaceutical R&D: Used in drug metabolism and pharmacokinetics (DMPK) research to track the absorption, distribution, metabolism, and excretion (ADME) of Penicillamine.
• Clinical Research & Diagnostics: Enables accurate measurement of Penicillamine levels in patient plasma, serum, or urine for therapeutic drug monitoring (TDM) and clinical trial analysis.
• Biomarker Analysis: Facilitates the study of Penicillamine's role and concentration in relation to specific disease states or physiological processes.
• Method Development & Validation: Serves as a key component in developing and validating robust, regulatory-compliant (e.g., FDA, EMA) bioanalytical methods.
• Reference Material: Acts as a certified reference material (CRM) for calibrating analytical instruments and ensuring data integrity across laboratories.

Basic Information

Product Name	L-Penicillamine-D6
CAS No.	1795786-79-6
Molecular Formula	C5H5D6NO2S
Molecular Weight	167.26 g/mol
Synonyms	(2S)-2-Amino-3-methyl-3-(trideuteriomethyl)butanoic acid; (2S)-2-Amino-3-methyl-3-((2H3)methyl)butanoic acid; D-Penicillamine-d6 (incorrect stereochemistry); β,β-Dimethylcysteine-d6; 3-Mercapto-D-valine-d6; (S)-3,3-Dimethylcysteine-d6; Deuterated L-Penicillamine; L-Penicillamine (hexadeuterated)
EINECS	Contact for details

Quality Control

Our L-Penicillamine-D6 is manufactured under strict quality systems to ensure the highest isotopic and chemical purity required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry, to confirm identity, isotopic enrichment (typically ≥98 atom % D), and chemical purity (typically ≥95%). A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Isotopic Purity	≥ 98 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.