Description

L-Leucine 2-[(2-Amino-1,6-Dihydro-6-Oxo-9H-Purin-9-Yl)Methoxy](Ethyl-D4) Ester Hydrochloride is a high-purity, deuterated nucleoside analog derivative designed for advanced research and development. This compound is critical for metabolic and pharmacokinetic studies, particularly in the development of antiviral and anticancer therapeutics, where its deuterated ethyl ester moiety provides enhanced stability and traceability. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on drug discovery, proteomics, and stable isotope labeling.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for quality control and analytical method development in drug manufacturing.
• Metabolic Pathway Tracing: Used in mass spectrometry-based studies to track drug metabolism and distribution due to its deuterium-labeled ethyl group.
• Antiviral/Anticancer Drug Development: Acts as a key synthetic intermediate or active pharmaceutical ingredient (API) precursor in nucleoside analog research.
• Proteomics & Biomarker Research: Employed in chemical proteomics for studying protein-nucleic acid interactions and identifying novel biomarkers.
• Stable Isotope Labeling: Essential for internal standard synthesis in quantitative LC-MS/MS bioanalysis, ensuring accurate pharmacokinetic data.
• Biochemical Research: Used to investigate enzyme mechanisms involving purine metabolism and nucleotide processing.

Basic Information

Product Name	L-Leucine 2-[(2-Amino-1,6-Dihydro-6-Oxo-9H-Purin-9-Yl)Methoxy](Ethyl-D4) Ester Hydrochloride
CAS No.	1795785-74-8
Molecular Formula	C19H27D4N7O5 • HCl
Molecular Weight	~ 502.0 g/mol (as hydrochloride salt)
Synonyms	9-[(2-((S)-1-Carboxy-3-methylbutylamino)-2-oxoethoxy)methyl]guanine Ethyl-d4 Ester Hydrochloride; L-Leucyl-2-[(2-Amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy](Ethyl-d4) Ester Hydrochloride; Deuterated Acyclovir Leucyl Ester Hydrochloride; 2-[(2-Amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-4-methyl-1-oxo-1-[(2,2,2-trideuteroethoxy)amino]pentan-2-aminium Chloride; Acyclovir Prodrug Deuterated Analog HCl; Guanosine Analog Deuterated Ester Salt; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our L-Leucine 2-[(2-Amino-1,6-Dihydro-6-Oxo-9H-Purin-9-Yl)Methoxy](Ethyl-D4) Ester Hydrochloride is manufactured under strict quality systems suitable for research and development. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and MS for isotopic enrichment verification. Certificates of Analysis (COA) detailing batch-specific results are available upon request to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C (refrigerated) or as indicated on the certificate of analysis. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines
Assay (HPLC)	90.0% - 110.0% of labeled amount

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.