Description

n-(Acetyl-D3)-S-[4-(2-Pyridinyl)Benzyl]-L-Cysteine is a deuterated, isotopically labeled derivative of a cysteine-based compound, featuring a pyridinylbenzyl moiety. This compound is specifically designed for use as a high-value internal standard or reference material in quantitative mass spectrometry-based analyses, where precision and accuracy are paramount. It is essential for researchers and quality control laboratories in the pharmaceutical, biotechnology, and contract research organization (CRO) sectors, particularly for drug metabolism and pharmacokinetics (DMPK) studies, proteomics, and biomarker validation.

Application

• Internal Standard for LC-MS/MS: Primary application as a stable isotope-labeled internal standard for the precise quantification of its non-deuterated counterpart or related metabolites in complex biological matrices.
• Drug Metabolism & Pharmacokinetics (DMPK): Critical for absorption, distribution, metabolism, and excretion (ADME) studies to track drug candidate pathways and improve pharmacokinetic modeling.
• Proteomics & Metabolomics Research: Used in targeted and untargeted mass spectrometry workflows for the relative and absolute quantification of peptides, proteins, or small molecule metabolites.
• Biomarker Discovery & Validation: Enables accurate measurement of potential disease biomarkers in clinical and preclinical research settings.
• Pharmaceutical Impurity Profiling: Assists in the identification and quantification of process-related impurities or degradation products during drug development and manufacturing.
• Stable Isotope Labeling in Chemical Synthesis: Serves as a building block for synthesizing more complex deuterated molecules for various research applications.

Basic Information

Product Name	n-(Acetyl-D3)-S-[4-(2-Pyridinyl)Benzyl]-L-Cysteine
CAS No.	1795785-71-5
Molecular Formula	C₁₇H₁₅D₃N₂O₃S
Molecular Weight	333.40 g/mol
Synonyms	L-Cysteine, N-(acetyl-d3)-S-[4-(2-pyridinyl)benzyl]-; N-(Acetyl-d3)-S-[4-(2-Pyridinyl)benzyl]-L-cysteine; N-Acetyl-d3-S-(4-(pyridin-2-yl)benzyl)-L-cysteine; Deuterated Acetyl Cysteine Pyridinylbenzyl Derivative; (2R)-2-acetamido-3-[[4-(pyridin-2-yl)phenyl]methyl]sulfanyl-d3-propanoic acid
EINECS	Contact for details

Quality Control

Every batch of n-(Acetyl-D3)-S-[4-(2-Pyridinyl)Benzyl]-L-Cysteine is manufactured and analyzed under strict quality management systems. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with research-grade standards and precise isotopic enrichment. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic purity (D-enrichment), and identity is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to maintain purity and prevent degradation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.