Description

N'-(4-Acetylaminophenyl)-N,n-Dimethylacetamidine-D6 is a deuterated isotopologue of a key acetamidine derivative, serving as a critical stable isotope-labeled internal standard for analytical quantification. This high-purity compound is essential for ensuring accuracy and reliability in mass spectrometry-based methods, particularly in pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers requiring precise measurement of the non-deuterated parent compound in complex biological matrices.

Application

• Primary use as a stable isotope-labeled internal standard (SIL-IS) for Liquid Chromatography-Mass Spectrometry (LC-MS/MS) bioanalysis.
• Quantification of the non-deuterated parent drug in pharmacokinetic (PK) and toxicokinetic (TK) studies during drug development.
• Metabolite identification and profiling studies to track drug disposition and biotransformation pathways.
• Method development and validation in regulated bioanalytical laboratories to meet FDA/EMA guidelines.
• High-throughput screening assays where precise and reproducible quantification is paramount.
• Use in clinical research for monitoring drug concentrations in patient plasma, serum, or urine samples.

Basic Information

Product Name	N'-(4-Acetylaminophenyl)-N,n-Dimethylacetamidine-D6
CAS No.	1795137-54-0
Molecular Formula	C12H10D6N3O
Molecular Weight	~212.28 g/mol
Synonyms	N'-(4-Acetamidophenyl)-N,N-dimethylacetamidine-d6; N,N-Dimethyl-N'-[4-(acetylamino)phenyl]acetamidine-d6; 4-(N',N'-Dimethylacetamidino)acetanilide-d6; Deuterated Acetamidine Internal Standard; Acetamidine-d6 Derivative; [D6]-Labeled N'-(4-Acetylaminophenyl)-N,N-dimethylacetamidine; SIL-IS for Acetamidine Analogs
EINECS	Contact for details

Quality Control

Every batch of N'-(4-Acetylaminophenyl)-N,n-Dimethylacetamidine-D6 is manufactured and tested to meet the stringent requirements for isotope-labeled reference materials. Our quality assurance includes rigorous analysis for isotopic purity (D-enrichment), chemical purity, and identity confirmation. Certificates of Analysis (COA) are provided, detailing results from NMR, HPLC, and MS to ensure compliance with internal specifications and customer application needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.