Description

3-Methyl-2-Oxovaleric Acid-D8 Sodium Salt (Major) is a high-purity, isotopically labeled sodium salt of a key branched-chain keto acid derivative. This compound serves as a critical internal standard and reference material in advanced analytical chemistry, ensuring precise quantification and method validation. It is primarily utilized by research scientists and quality control laboratories in the pharmaceutical, metabolomics, and clinical diagnostics sectors for stable isotope dilution mass spectrometry (IDMS) and other quantitative analytical techniques.

Application

• Internal Standard for LC-MS/MS: Essential for the accurate quantification of endogenous 3-methyl-2-oxovaleric acid and related metabolites in complex biological matrices like plasma, urine, and tissue homogenates.
• Metabolomics Research: Used in targeted and untargeted metabolomic studies to investigate metabolic pathways, disease biomarkers, and the effects of drug interventions.
• Clinical Diagnostics: Supports the development and validation of diagnostic assays for inborn errors of metabolism, such as maple syrup urine disease (MSUD).
• Pharmaceutical R&D: Employed in pharmacokinetic (PK) and pharmacodynamic (PD) studies to track drug metabolism and understand biochemical mechanisms of action.
• Stable Isotope Labeling: Acts as a tracer in metabolic flux analysis to study the dynamics of metabolic networks in cells and organisms.
• Quality Control & Method Validation: Provides a benchmark for ensuring the accuracy, precision, and reproducibility of analytical methods in contract research organizations (CROs) and regulatory environments.

Basic Information

Product Name	3-Methyl-2-Oxovaleric Acid-D8 Sodium Salt (Major)
CAS No.	1795037-03-4
Molecular Formula	C6H2D8NaO3
Molecular Weight	Contact for details
Synonyms	2-Keto-3-methylvaleric acid-d8 sodium salt; 3-Methyl-2-oxopentanoic acid-d8 sodium salt; Sodium 3-methyl-2-oxovalerate-d8; α-Keto-β-methylvaleric acid-d8 sodium salt; (Major) Isotopologue of 3-Methyl-2-oxovaleric acid sodium salt; BCKA-d8 sodium salt (Branched-chain keto acid); MOVA-d8 Sodium Salt; Deuterated Sodium 3-Methyl-2-oxopentanoate
EINECS	Contact for details

Quality Control

Every batch of 3-Methyl-2-Oxovaleric Acid-D8 Sodium Salt (Major) is manufactured and analyzed under strict quality management protocols. We guarantee high chemical and isotopic purity through comprehensive analytical techniques including NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, isotopic enrichment, and other critical specifications to support your research and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation and storage under inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 2.0 %
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.