Description

Diethylcarbamazine-D3 Citrate is a deuterated analog of the anthelmintic drug diethylcarbamazine, specifically labeled with three deuterium atoms. This stable isotope-labeled compound is essential for use as an internal standard in quantitative bioanalytical methods, ensuring the highest accuracy and reliability in pharmacokinetic and metabolic studies. It is a critical material for pharmaceutical research and development laboratories, contract research organizations (CROs), and analytical service providers focused on advancing therapeutic treatments for parasitic diseases.

Application

• Primary use as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for the quantification of diethylcarbamazine in biological matrices.
• Facilitates drug metabolism and pharmacokinetics (DMPK) studies to understand the absorption, distribution, metabolism, and excretion (ADME) profile of the parent drug.
• Enables high-precision bioanalytical method development and validation in compliance with FDA, EMA, and ICH guidelines.
• Supports clinical trial research for filariasis and other parasitic infections by providing a reliable reference for patient sample analysis.
• Used in forensic and anti-doping analysis for the definitive identification and measurement of diethylcarbamazine.
• Critical for stable isotope dilution assays to achieve superior accuracy and correct for matrix effects and instrument variability.

Basic Information

Product Name	Diethylcarbamazine-D3 Citrate
CAS No.	1795031-70-7
Molecular Formula	C₁₀H₂₀D₃N₃O•C₆H₈O₇
Molecular Weight	391.42 g/mol
Synonyms	Diethylcarbamazine-d3 Citrate Salt; 1-Diethylcarbamyl-4-methylpiperazine-d3 Citrate; N,N-Diethyl-4-methyl-1-piperazinecarboxamide-d3 Citrate; DEC-d3 Citrate; Hetrazan-d3 Citrate; Banocide-d3 Citrate; Notezine-d3 Citrate; Carbilazine-d3 Citrate
EINECS	Contact for details

Quality Control

Our Diethylcarbamazine-D3 Citrate is manufactured under strict quality systems to ensure exceptional isotopic purity and chemical integrity, suitable for the most demanding analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic purity (Atom % D), chemical purity (by HPLC), and confirmation of structure. We support research compliant with ICH Q2(R1) and FDA bioanalytical method validation guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity	≥99.0 Atom % D
Chemical Purity (by NMR)	Conforms
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.