Description

2,3,4,9-Tetrahydro-3-(Methylamino)-1H-Carbazole-6-Carbonitrile-D3 is a deuterated analog of a key carbazole derivative, serving as a crucial isotopically labeled intermediate in advanced pharmaceutical research and development. Its primary value lies in enabling precise metabolic and pharmacokinetic studies, providing critical data for drug discovery programs. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require high-purity, stable-isotope labeled building blocks for the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A vital labeled precursor in the synthesis of deuterated drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Metabolic Tracer: Used in Drug Metabolism and Pharmacokinetics (DMPK) studies to track the fate of parent compounds and metabolites in biological systems.
• Internal Standard for Bioanalysis: Employed in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for the accurate quantification of analytes in complex matrices.
• Mechanism of Action (MoA) Studies: Facilitates research into enzymatic pathways and receptor binding mechanisms by providing a non-radioactive isotopic label.
• Process Chemistry & Scale-up: Supports the development and optimization of synthetic routes for deuterated active pharmaceutical ingredients (APIs).
• Reference Standard: Serves as a certified reference material for quality control and regulatory submissions in drug development.

Basic Information

Product Name	2,3,4,9-Tetrahydro-3-(Methylamino)-1H-Carbazole-6-Carbonitrile-D3
CAS No.	1794979-58-0
Molecular Formula	C14H12D3N3
Molecular Weight	226.30 g/mol (approx.)
Synonyms	3-(Methylamino)-1H-carbazole-6-carbonitrile-2,3,4,9-tetrahydro-D3; Deuterated Carbazole Nitrile Intermediate; 6-Cyano-3-(methylamino)-2,3,4,9-tetrahydro-1H-carbazole-d3; Tetrahydrocarbazole-d3 derivative; Labeled THCA intermediate; D3-Labeled Methylamino Carbazole Carbonitrile; [D3]-2,3,4,9-Tetrahydro-3-(methylamino)-1H-carbazole-6-carbonitrile
EINECS	Contact for details

Quality Control

Our 2,3,4,9-Tetrahydro-3-(Methylamino)-1H-Carbazole-6-Carbonitrile-D3 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for chemical and isotopic purity, NMR for structural confirmation, and MS for identity verification. We provide comprehensive Certificates of Analysis (COA) detailing all specifications, ensuring traceability and compliance with research-grade material standards. Custom synthesis and purification to meet specific project requirements are available.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive (store away from light). For long-term storage, consider storing under an inert atmosphere to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content, MS)	≥ 98 atom % D
Chemical Purity (by HPLC)	≥ 97.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.